Prof. Dr. Christiane Fuchs "Estimating single-cell regulatory heterogeneities from cell populations"
- Di, 31. Juli 2018, 17:00 h - 18:00 h
- Small Seminar Room 8G U1 106 - München, _
- ISD Scientific Talks
Speaker: Prof. Dr. Christiane Fuchs,
Data Science Grou, Bielefeld University, Biostatistics Group, Institute of Computational Biology, Helmholtz Zentrum München
Topic: "Estimating single-cell regulatory heterogeneities from cell populations"
Cell-to-cell variation in gene regulation occurs in a number of biological contexts, such as development and cancer. Discovering regulatory heterogeneities in an, unbiased manner is difficult owing to the population averaging that is required for most global molecular methods. Here, we show that we can infer single-cell ,regulatory states by mathematically deconvolving global measurements taken as ,averages from small groups of cells. This averaging-and-deconvolution approach allows us to quantify single-cell regulatory heterogeneities while avoiding them, measurement noise of global single-cell techniques.
Time: Tuesday, July 31st, 2018, 5pm
Place: CSD Small Seminar room 8G U1 106
Host: Ozgun Gokce
- Small Seminar Room 8G U1 106